An efficient synthesis of gamma-amino beta-ketoester by cross-Claisen condensation with alpha-amino acid derivatives

摘要

Cross-ester condensation between N-protected amino acid ester and the lithium enolate prepared from alyl acetate gave the corresponding beta-ketoester in high yield without the formation of the tertiary alcohol that is commonly seen as by-product. This interesting reaction is applicable to the amino acid derivatives with suitable N-protecting groups, which can help to stabilize and reaction intermediates.