Dibutyltin dimethoxide-catalyzed aldol reaction of enol trichloroacetates

摘要

A catalytic aldol condensation of aldehydes with enol trichloroacetates was achieved using dibutyltin dimethoxide as a novel catalyst in a mixed solvent consisting of THF and MeOH. Various β-hydroxy ketones were distereoselectively obtained in high yields up to 99%.