Facile synthesis of chiral 2-formyl-1,1'-binaphthyl via lipase-catalyzed acylation and hydrolysis of 1,1'-binaphthyl oximes

摘要

Lipase-catalyzed acylation of 2-hydroxyiminomethyl-1,1'-binaphthyl [(±)-1] and hydrolysis of 2-acetoxyiminomethyl-1,1'-binaphthyl [(±)-2] yielded optically active oximes 1 and 2 with high enantiomeric excess. Successful synthesis of the optically active aldehyde 4 from chiral O-acetyl oxime 2 occurred without a decrease of enantiomeric excess.