Asymmetric synthesis of novel β-substituted β-methoxyacrylates bearing a chiral 1,2-cis-disubstituted cyclopropane substructure

摘要

The first asymmetric synthesis of β-substituted β-methoxyacrylate bearing a chiral 1,2-cis-disubstituted cyclopropane ring as a 'conformationally locked' substructure, by Claisen condensation and E-selective Wittig reaction was successfully achieved.