Facile preparative HPLC enantioseparation of racemic drugs using chiral stationary phases based on mono-6~A-azido-6~A-deoxy-perphenylcarbamoylated #beta#-cyclodextrin immobilized on silica gel

摘要

Immobilized chiral stationary phases (CSP)s from mono-6~A-azido-6~A-deoxy-perphenylcarbamoylated #beta#-cyclodextrin were prepared using an extended application of the Staudinger reaction. Their application in preparative enantioseparations of racemic mixtures was demonstrated using atropine, bendroflumethiazide and four #beta#-adrenergic blocking agents under reversed phase conditions.