Process for preparing (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid, and (-)-chiral stationary phases for resolution of racemic compounds using the same

摘要

The present invention relates to a process for preparing ()-(18-crown-6)-2,3,11,12-tetracarboxylic acid and its use for ()-chiral stationary phases for resolution of racemic compounds. More particularly, the present invention relates to the process for preparing ()-(18-crown-6)-2,3,11,12-tetracarboxylic acid expressed by formula (1) and the use thereof as a stationary phases for resolution of racemic compounds, wherein the use of them provides excellent separation of a desired chiral compound from racemic mixture in employing capillary electrophoresis (CE) or liquid chromatography to elute the desired one first by controlling a flowing order of enantioners, thus allowing to be consistently separated in an economical due to much less requirement of eluent, quantitative and high purity manner.