Enantioselective divergent total syntheses of fawcettimine-type Lycopodium alkaloids

摘要

Enantioselective divergent total syntheses of (+)-fawcettimine, (+)-fawcettidine, (+)-lycoflexine, (+)-lycoposerramine Q, (-)-Huperzine Q and (+)-N-oxyhuperzine Q have been described from a common precursor. The syntheses feature a vinylogous Rubottom oxidation and several biomimetic transformations. (C) 2014 Elsevier Ltd. All rights reserved.