Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines

Macreadie IG; Avery TD; Robinson TV; Macreadie P; Barraclough M; Taylor DK; Tiekink ERT

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Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines

机译：具有抗念珠菌活性的1,2-二恶英的设计：芳族取代的1,2-二恶英

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In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure-activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were assessed primarily against the pathogenic yeast, Candida albicans, with haemolytic activity of selected examples also reported. (c) 2007 Elsevier Ltd. All rights reserved.

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《Tetrahedron》 |2008年第7期|共8页
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Macreadie IG; Avery TD; Robinson TV; Macreadie P; Barraclough M; Taylor DK; Tiekink ERT;
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正文语种 eng
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antifungal; 1; 2-dioxine; Candida; epoxy; 1; 2-dioxine; haemolytic activity; ENDOPEROXIDES;

机译：抗真菌;1;2-二恶烷;念珠菌;环氧树脂;1;2-二恶英;溶血活性;内毒素;

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1. Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines [J] . Macreadie IG, Avery TD, Robinson TV, Tetrahedron . 2008,第7期

机译：具有抗念珠菌活性的1,2-二恶英的设计：芳族取代的1,2-二恶英
2. Transition metal-free diastereospecific synthesis of (Z)-2-arylidene-2,3-dihydrobenzo[b][1,4]dioxines by reaction of (Z)-1,2-dibromo-3-aryl-2-propenes with catechols [J] . Rekowski Szymon P., Wani Aabid A., Conrad Juergen, Tetrahedron . 2020,第42期

机译：通过（Z）-1,2-二溴-3-芳基-2-丙烯-2-丙烯 - 2-丙烯 - 2-丙烯 - 2-丙烯-2-丙烯 - 2 - 丙烯 - 2-丙烯-2-丙烯（Z）-2-亚芳基-2,3-二氢苯基[B] [1,4]二氧胺的过渡无金属非致映射合成儿茶酚
3. A domino Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines and application to the synthesis of the ceramide transport inhibitor (+/-)-HPA-12 [J] . Legendre Sarah V. A. -M., Jevric Martyn, Klepp Julian, Tetrahedron . 2018,第12期

机译：3,6-二氢-1,2-二恶英的Domino Kornblum-Delamare / AZA-Michael反应和应用于神经酰胺转运抑制剂的合成（+/-） - HPA-12
4. Methyl(11aS)-1,2,3,5,11,11a-Hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-3',4':1,2pyridin3,4-b-indol-2-Substituted Acetates: Synthesis and Three-Dimensional Quantitative Structure-Activity Relationship Investigation as a Class of Novel Vasodilator [C] . Jiawang Liu, Ming Zhao, Guohui Cui, 第四届国际分子模拟与信息技术应用学术会议（The 4th International Conference of Molecular Simulations and Applied Informatics Technologies）论文集 . 2008

机译：甲基（11aS）-1,2,3,5,11,11a-六氢-3,3-二甲基-1-氧代-6H-咪唑-3'，4'：1,2吡啶3,4- b-吲哚-2-取代的乙酸酯：一类新型血管扩张剂的合成与三维定量构效关系研究
5. I. SYNTHETIC APPROACHES TO SUBSTITUTED 2-OXABICYCLO(3.2.1)OCTANE DERIVATIVES AND II. THE SYNTHESIS OF 1-SUBSTITUTED DERIVATIVES OF ANHYDRO (3-CHLOROACETYL-2-HYDROXYIMIDAZO(1,2-A)PYRIDINIUM HYDROXIDE). [D] . FRIEDMAN, ALAN E. 1973

机译：I.取代2-氧杂双环（3.2.1）正己烷衍生物的合成方法和II。合成1-取代的酸酐（3-氯乙酰基-2-羟基咪唑并（1,2-A）吡啶鎓氢氧化物）。
6. Correction: Design, synthesis, crystal structure and fungicidal activity of (E)-5-(methoxyimino)-3,5-dihydrobenzo[e][1,2]oxazepin-4(1H)-one analogues [O] . Dongyan Yang, Chuan Wan, MengMeng He, 1924

机译：校正：（E）-5-（甲氧基亚氨基）-3,5-二氢苯并[e] [1,2]草氮杂-4（1H）-one类似物的设计，合成，晶体结构和杀真菌活性
7. Crystal structure of (2S,3S,4aR,6aS,7aR,7bR)-methyl 2,3-dimethoxy-2,3-dimethyl-3,4a,6a,7,7a,7b-hexahydro-2H-cyclopropa[3,4]benzo-[1,2-b]dioxine-6-carboxylate, C$_{15}$H$_{22}$O$_{6}$ [O] . Frey, Wolfgang, Hausmann, Tobias, Pietruszka, Jörg 2011

机译：（2S，3S，4aR，6aS，7aR，7bR）-甲基2,3-二甲氧基-2,3-二甲基-3,4a，6a，7,7a，7b-六氢-2H-环丙烷[3， 4]苯并[[1,2-b]二恶英-6-羧酸盐，C $ _ {15} $ H $ _ {22} $ O $ _ {6} $

Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines

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