Synthesis of the JKLM-ring fragment of ciguatoxin

摘要

A stereoselective synthesis of the LM-ring fragment has been achieved starting from a sugar derivative. A stereoselective synthesis of the JKLM-ring fragment has been achieved through a coupling between two segments via heteroconjugate addition, seven-membered ether ring formation mediated by an acetylene cobalt complex, and spiroketalization reaction. (C) 2003 Elsevier Ltd. All rights reserved. [References: 87]