Profiling Serotonin Reuptake Inhibitors (SSRIs) in the Environment: Trends in Analytical Methodologies

摘要

Selective serotonin reuptake inhibitor (SSRI) antidepressants are among the most prescribed Pharmaceuticals worldwide and are ubiquitous in different areas of the environment. There are few reliable and specific analytical methods for the detection and quantification of SSRIs in environmental samples. The majority of the reported methods generally involve cleanup procedures that usually employ solid-phase extraction (SPE) followed by liquid chromatography with tandem mass spectrometry detection (LC-MS-MS). Herewith, a comprehensive overview of the described analytical methods available for the determination of SSRIs in environmental samples is provided. We address all steps involved in the analytical procedures, with the inherent advantages and disadvantages of each discussed.