SIMPLE AND EFFICIENT METHOD FOR THE SYNTHESIS OF 1-((ARYL)(2-OXOINDOLIN-3-YL-) METHYL)UREA AND 1-((ARYL)(2-OXOINDOLIN-3-YL-)METHYL)THIOUREA DERIVATIVES

摘要

A number of new1-((aryl)(2-oxoindolin-3-yl)methyl)urea and 1-((aryl) (2-oxoindolin-3-yl)methyl)thiourea derivatives have been prepared by simply combining 2-indolinone, aromatic aldehyde, and urea or thiourea in the presence of π-TsOHin EtOH. This newmethodology affords the title compounds in good yields and without the use of chromatography.