A Carbonylation Approach Toward Activation of C-sp2-H and C-sp3-H Bonds: Cu-Catalyzed Regioselective Cross Coupling of Imidazo[1,2-a]pyridines with Methyl Hetarenes

摘要

An efficient topper-catalyzed selective cross coupling of imidato [1,2-a]pyridines with methyl hetarenes has been reported. This transformation opened a new route to synthesize the C-3 carbonyl imidazo[1,2-a]pyridine derivative, which is a common structural motif in natural products, and pharmaceuticals. O-18-labeling experiments indicated that the oxygen source of products originated from O-2.