Tandem C?2 Functionalization?Intramolecular Azide?Alkyne 1,3?Dipolar Cycloaddition Reaction: A Convenient Route to Highly Diversified 9H?Benzo[b]pyrrolo[1,2?g][1,2,3]triazolo[1,5?d][1,4]diazepines

摘要

An efficient diversity-oriented synthetic approach to annulated 9H-benzo[b]pyrrolo[1,2-g][1,2,3]- triazolo[1,5-d][1,4]diazepines has been developed using a Sc(OTf)3-catalyzed two-component tandem C-2 functionalization? intramolecular azide?alkyne 1,3-dipolar cycloaddition reaction. The reaction shows high substrate tolerance and provides a library of fused heterocycles that may lead to novel biologically active compounds or drug lead molecules.