One-Pot Synthesis of Highly Substituted 4?Acetonylindoles via Sequential Dearomatization and Silver-Catalyzed Domino Reaction

摘要

Synthetically useful 4-acetonylindoles have been conveniently prepared from 2-alkynylanilines and silyl enol ethers using a dearomatization strategy. The two-step/one-pot protocol involves an iodosylbenzene-mediated oxidative dearomatization and a silver-catalyzed domino reaction.