Stereoselective radical amination of electron-deficient C(sp ~3)-H bonds by Co(II)-based metalloradical catalysis: Direct synthesis of α-amino acid derivatives via α-C-H amination

摘要

The cobalt(II) complex of 3,5-Di tBu-IbuPhyrin, [Co(P1)], is an effective catalyst for intramolecular amination of electron-deficient C-H bonds, including those adjacent to electron-withdrawing CO _2R, C(O)NR _2, C(O)R, and CN groups, in excellent yields with high regio- and stereoselectivity. The [Co(P1)]-catalyzed amination system provides a direct method for the synthesis of α-amino acid derivatives from the corresponding carboxylate precursors.