Transition-metal-free C-C bond cleavage and formation: efficient synthesis of 2,3-diarylimidazo [1,2-alpha]pyridines from 2-aminopyridines and alkynoates

摘要

A highly efficient transition-metal- free cyclization reaction for the synthesis of 2,3-diarylimidazo[1,2-alpha]pyridines is described. A variety of substituted 2-aminopyridines and alkynoates are compatible under the standard conditions. This protocol is marked by the cleavage of a C-C bond and the formation of a new C-sp(2)-C-sp(2) bond under transition-metal-free conditions.