Effects of proinflammatory cytokines and hemofiltration on ventricular repolarization in septic shock

摘要

Sepsis, one of the leading causes of death in intensive care units, is a proinflammatory and procoagulant systemic response to invading pathogens. Despite aggressive treatment mortality ranges from 15% in patients with sepsis to 40%-60% in patients with septic shock (1). The patients die of multiple organ failure, refractory hypotension, and fatal ventricular arrhythmias have also been frequently reported (2, 3).