Palladium-Catalyzed Oxidative Synthesis of Aromatic Ketones Using Olefins as Acyl Equivalents through Selective ortho Aromatic C–H Bond Activation

摘要

An efficient catalytic system has been developed for selective ortho-acylation of arenes by oxidative C–H bond activation using a palladium catalyst. Olefins were oxidized to the corresponding aldehydes/benzoyl radicals, which, on coupling with 2-phenylpyridine, gave the corresponding acylated products in good to excellent yields. 1-Phenylpyrazole also reacts with substituted olefins to give the acylation products in good yields.