The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown

Abu El-Asrar Ahmed M.; Mohammad Ghulam; Nawaz Mohd Imtiaz; Abdelsaid Mohammed; Siddiquei Mohammad Mairaj; Alam Kaiser; Van den Eynde Kathleen; De Hertogh Gert; Opdenakker Ghislain; Al-Shabrawey Mohamed; Van Damme Jo; Struyf Sofie

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The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown

机译：趋化因子血小板因子4变异体（PF-4var）/ CXCL4L1抑制糖尿病诱导的血视网膜屏障破坏。

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PURPOSE. To investigate the expression of platelet factor-4 variant (PF-4var/CXCL4L1) in epiretinal membranes from patients with proliferative diabetic retinopathy (PDR) and the role of PF-4var/CXCL4L1 in the regulation of blood-retinal barrier (BRB) breakdown in diabetic rat retinas and human retinal microvascular endothelial cells (HRMEC).

机译：目的。调查血小板因子4变异体（PF-4var / CXCL4L1）在增生性糖尿病视网膜病变（PDR）患者的视网膜前膜中的表达以及PF-4var / CXCL4L1在调节血视网膜屏障（BRB）分解中的作用在糖尿病大鼠视网膜和人视网膜微血管内皮细胞（HRMEC）中。

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《Investigative ophthalmology & visual science》 |2015年第3期|共9页
作者
Abu El-Asrar Ahmed M.; Mohammad Ghulam; Nawaz Mohd Imtiaz; Abdelsaid Mohammed; Siddiquei Mohammad Mairaj; Alam Kaiser; Van den Eynde Kathleen; De Hertogh Gert; Opdenakker Ghislain; Al-Shabrawey Mohamed; Van Damme Jo; Struyf Sofie;
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正文语种 eng
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diabetic retinopathy; blood-retinal barrier; platelet factor-4 variant (PF-4var/CXCL4L1);

机译：糖尿病性视网膜病变;血视网膜屏障;血小板因子4变异（PF-4var / CXCL4L1）;

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1. The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown [J] . Abu El-Asrar Ahmed M., Mohammad Ghulam, Nawaz Mohd Imtiaz, Investigative ophthalmology & visual science . 2015,第3期

机译：趋化因子血小板因子4变异体（PF-4var）/ CXCL4L1抑制糖尿病诱导的血视网膜屏障破坏。
2. Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells. [J] . Vandercappellen J, Noppen S, Verbeke H, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2007,第6期

机译：在正常和肿瘤间充质细胞中刺激血管生成血小板因子4变体（CXCL4L1 / PF-4var）与抑制血管生成性粒细胞趋化蛋白2（CXCL6 / GCP-2）的关系。
3. Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3. [J] . Struyf S, Salogni L, Burdick MD, Blood: The Journal of the American Society of Hematology . 2011,第2期

机译：CXC趋化因子CXCL4L1（血小板因子4变体）的血管抑制和趋化活性由CXCR3介导。
4. The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood–Retinal Barrier Breakdown [O] . Ahmed M. Abu El-Asrar, Ghulam Mohammad, Mohd Imtiaz Nawaz, -1

机译：趋化因子血小板因子4变异体（PF-4var）/ CXCL4L1抑制糖尿病诱导的血液-视网膜屏障破坏
5. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis [O] . Struyf, Sofie, Burdick, Marie D, Proost, Paul, 2004

机译：血小板释放CXCL4L1，它是趋化因子血小板因子4 / CXCL4的非等位变体，是血管新生的有效抑制剂

The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood-Retinal Barrier Breakdown

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