Synthesis, Spectral Characterization, Grain Size Effect, Antimicrobial, DNA Cleavage and Anticancer Activities of Cobalt(II), Nickel(II), Copper(II) and Zinc(II) Complexes of Schiff Base

摘要

A series of cobalt(II), nickel(II), copper(II) and zinc(II) complexes were synthesized with a newly prepared Schiff base ligand. The ligand was prepared by the condensation of indole-3-carboxaldehyde with 2-amino-3-carboxyethyl-4,5-dimethylthiophene (1:1 molar ratio). The complexes were characterized by elemental analysis, molar conductance, magnetic moment, UV-visible, IR, ~1H NMR and mass spectrometric techniques. From the results of physico-chemical and spectral techniques, tetrahedral and square planar geometry have been proposed for these metal complexes. The crystallinity and surface morphologies of the metal-complexes were examined by powder XRD and SEM. Antibacterial and antifungal activities of the metal-complexes were screened by Kirby-Bauer disk diffusion method. DNA cleavage was investigated using the Gel-electrophoresis method. The super oxide anion scavenging and anticancer activities of the metal-complexes against HeLa cell line were determined using MTT assay.