Preparation and Characterization of Primary Amines by Potassium Borohydride-Copper Chloride System from Nitriles

摘要

Nitriles undergo reduction to primary amines under optimized conditions at 50 °C using 0.25 equiv of copper chloride and 3.0 equiv of potassium borohydride in 80 % isopropanol. The aromatic and aralkyl nitriles could be effectively reduced in yield ranging from 60 to 90%.