Preparation, Characterization and Evaluation of Dissolution and Taste Masked Enrofloxacin Formulations using Inclusion/Solid Dispersion/Ion-Exchange Resin Approach

摘要

In the present study, solid dispersion and ion-exchange resin techniques were widely used for improving drugs dissolution properties. Several techniques were used to analyze the properties of these enrofloxacin (ENR) formulations, using differential scanning calorimetry, X-ray diffraction, Fourier transform infrared, dissolution study and masking taste. The results obtained showed that the rate of dissolution of enrofloxacin was greatly improved when formulated in ENR/PVP K30 solid dispersion as compared with other formulations and pure enrofloxacin. Ion-exchange resin had the best effect on masking taste.