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Novel MCR Synthesis of Post Transition Metal Complexes with Substituted Hydroxy Quinolines as Potent Antimicrobial Agent

机译:以取代的羟基喹啉为有效抗菌剂的新型MCR合成过渡金属配合物

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A series of Ni(II), Cu(II) and Zn(II) complexes have been synthesized by condensation and cyclization methodology. The ligand was synthesized by MCR (multi component reaction) of ortho toluidine, ethyl acetoacetate and triethyl ortho-formate and the condensed product was further cyclized in dowtherm A. The synthesized ligand was reacted with M(CH3COO)2 (M = Ni, Cu or Zn), to get complexes. The synthesized metal complexes and ligand were characterized by FT-IR, Mass, X-ray crystallography and atomic absorption. The ligand as well as metal complexes were also screened for antimicrobial activities. The data showed that complexes exhibited more biological activities than ligand.
机译:通过缩合和环化方法合成了一系列的Ni(II),Cu(II)和Zn(II)配合物。通过邻甲苯胺,乙酰乙酸乙酯和原甲酸三乙酯的MCR(多组分反应)合成配体,并将缩合产物进一步在Dowtherm A中环化。合成的配体与M(CH3COO)2(M = Ni,Cu或Zn)以得到络合物。通过FT-IR,质谱,X射线晶体学和原子吸收对合成的金属配合物和配体进行了表征。还筛选了配体以及金属配合物的抗微生物活性。数据表明,复合物比配体表现出更多的生物活性。

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