Synthesis, Characterization and Antitumor Studies of Two Copper(II) Schiff Base Complexes Derived from Glutathione and o-Vanillin

摘要

Two new copper Schiff base complexes (Cu2C_(19)H_(31)N3O_(11)S (1), Cu2(C_(18)H_(23)N3O8S) (C_(12)H8N2)2) (2) [C_(18)H_(23)N3O8S = HL (Schiff base derived from glutathione and o-vanillin), C_(12)H8N2 = 1,10-phenanthroline] were synthesized and characterizated by elemental analysis, IR spectroscopy, 'H NMR and thermogravimetric analysis. The test of cell proliferation observed that complex 2 binding with 1,10-phenanthroline are more potent apoptosis inducers in MDA MB 231 cells than complex 1. Furthermore, our study suggests that complex 2 is capable of inhibiting tumor cellular proteasome activity and induce cancer cell-specific apoptotic death.