Two-Step Synthesis of Some Novel Monoindolylmaleimides

摘要

Monoindolylmaleimides have been identified as potent glycogen synthase kinase-3|3 inhibitors. In this paper, a convenient methodology for the preparation of some new monoindolylmaleimides was developed by microwave assisted condensation of substituted monochloromaleimides with N-containing heterocycles followed by ammonolysis in good overall yield (up to 80 %). The products were characterized by ~1H NMR and ESI-MS.