The safety of subcutaneously administered depot medroxyprogesterone acetate (104 mg/0.65 mL): A systematic review

摘要

Context: Depot medroxyprogesterone acetate (DMPA), a progestogen-only contraceptive injectable, has traditionally been formulated as a crystalline suspension delivered intramuscularly (IM) at a dose of 150 mg/1.0 mL. A new, lower dose formulation of DMPA (104 mg/0.65 mL) has been developed for subcutaneous administration (SC). Given its increasing global availability and public health relevance, DMPA-SC was prioritized for inclusion as a new method referenced in the World Health Organization (WHO) Medical Eligibility Criteria for Contraceptive Use (MEC), 5th Edition.