Copper-Catalyzed Domino Cycloaddition/C-N Coupling/Cyclization/ (C—H Arylation): An Efficient Three-Component Synthesis of Nitrogen Polyheterocycles

摘要

Transition-metal-mediated cascade reactions constitute one of the most vibrant areas of modern-day organic chemistry. The efficiency of a catalytic system in these step-economical processes should be evaluated by the number and diversity of individual transformations involved and the number of new bonds that can be formed by the catalyst, as these factors are usually proportional to the complexity of the final products. From this point of view, it is not surprising that a significant portion of the existing catalytic cascade reactions have been based on palladium, which has highly versatile reactivity and well-understood mechanisms.