Sticky Nanoparticles: A Platform for sIRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functioiialized, Self-Assembled Nanocomjugate

摘要

Small interfering RNA (siRNA) has specific and effective gene silencing effects and has rapidly emerged as a potent strategy for cancer therapy. Naked siRNA cannot readily cross cellular membranes, and the delivery of siRNA to its target remains the biggest hurdle to clinical translation. Various types of synthetic nanovectors have been investigated for siRNA delivery. Although many promising systems for the delivery of siRNA have been reported, clinical translation of siRNA therapeutics remains a challenge. Herein, we report a nanoparticle-based system for delivering siRNA into cells that uses a biodegradable conjugate with a high cell permeability for targeting tumors, and a universal phosphate-binding analogue for high siRNA binding affinity.