Catalytic Asymmetric Intramolecular Hydroacylation with Rhodium/ Phosphoramidite-Alkene LIgand Complexes

摘要

The rational design and development of novel transition-metal catalysts bearing diolefin and phosphine-olefin ligands has recently gained attention for the promotion of catalytic enantioselective reactions such as conjugate and imine additions, as well as the cyclization of ynals. The heteroleptic complexes generated from phosphine-alkene ligands can be particularly useful as they include at least two donors with distinct steric and electronic properties. Phosphine-alkene ligands featuring dibenzo[b,f]azepine motifs have previously been reported in enantioselective allylic displacement and conjugate addition reactions.