Iridium-Catalyzed Asymmetric Allylic Substitutions—Very High Regioselectivity and Air Stability witha Catalyst Derived from Dibenzo[a,e]cydooctatetraene and a Phosphoramidite

摘要

Transition-metal-catalyzed asymmetric allylic substitutions are widely employed. Steric course and regioselectivity of these reactions vary considerably, depending on the metal ion, ligands, the nucleophile, and the leaving group. Today, Pd catalysts are usually employed for 1,3-disubstituted allylic substrates, while Ir catalysts serve well for a broad range of monosubstituted allylic substrates.