Self-Assembled Bifunctional Catalysis Induced by Metal Coordination Interactions: An Exceptionally Efficient Approach to Enantioselective Hydrophosphonylation

摘要

Enantiomerically enriched α-hydroxy-functionalized phos-phonates and phosphonic acids have been widely employed to synthesize pharmaceutically and biologically active compounds. Catalytic asymmetric hydrophosphonylation by addition of an appropriate phosphorus nucleophile to the carbonyl bond can provide a very convenient route to the corresponding optically active α-hydroxy phosphonates, which is probably the most general and widely applied approach.