Disruption of muscle renin-angiotensin system in AT_(1a)~(-/-) mice enhances muscle function despite reducing muscle mass but compromises repair after injury

摘要

The role of the renin-angiotensin system (RAS) in vasoregulation is well established, but a localized RAS exists in multiple tissues and exerts diverse functions including autonomic control and thermogenesis. The role of the RAS in the maintenance and function of skeletal muscle is not well understood, especially the role of angiotensin peptides, which appear to contribute to muscle atrophy. We tested the hypothesis that mice lacking the angiotensin type 1A receptor (AT_(1A)~(-/-)) would exhibit enhanced whole body and skeletal muscle function and improved regeneration after severe injury.