Role of NKT cells in the digestive system.IV. The role of canonical natural killer T cells in mucosal immunityand inflammation

摘要

First published October 18, 2007; doi:10.1152/ajpgi.00437.2007.-Lymphocytes that combine features of T cells and natural killer (NK) cells are named natural killer T (NKT) cells. The majority of NKT cells in mice bear highly conserved invariant Valpha chains, and to date two populations of such canonical NKT cells are known in mice: those that express Val4 and those that express Va7.2. Both populations are selected by nonpoly-morphic major histocompatibility complex class I-like antigen-presenting molecules expressed by hematopoietic cells in the thymus: CDld for Val4-expressing NKT cells and MR1 for those cells expressing Va7.2, The more intensely studied Valpha 14 NKT cells have been implicated in diverse immune reactions, including immune regulation and inflammation in the intestine; the Va7.2 expressing cells are most frequently found in the lamina propria. In humans, populations of canonical NKT cells are found to be highly similar in terms of the expression of homologous, invariant T cell antigen-receptor alpha-chains, specificity, and function, although their frequency differs from those in the mouse. In this review, we will focus on the role of both of these canonical NKT cell populations in the mucosal tissues of the intestine.