NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKca ion channel

摘要

maintenance of correct intraocular pressure (IOP) is a requirement for good vision. Two major factors contribute to IOP: the production of aqueous humor by the ciliary processes and the outflow of aqueous humor through the trabecular meshwork (TM) and Schlemm's canal; thus, increases in production and/or decreases in outflow facility of aqueous humor could result in high IOP. In fact, increased resistance to aqueous humor outflow through the juxtacanalicular region of the TM has been implicated in primary open angle glaucoma (35), a blinding disease that affects millions of people worldwide. Decreasing IOP is a viable strategy for preventing blindness caused by glaucoma and slowing its progression.