protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin

摘要

Zucker rats has been shown to induce insulin resistance and hyperinsulinemia, associated with an elevation in blood pressure (22), and development of vascular endothelial cell damages (35). It has also been shown that resveratrol improves vascular endothelial and postischemic cardiac function in various experimental models (11, 23, 27, 34), which suggests that this agent may change the outcome of myocardial infarction in the diabetic state. However, although resveratrol can protect the myocardium of nondiabetic subjects, there are currently no or little data available about the ability of resveratrol to protect the heart in genetically modified Zucker obese diabetic rats in the presence or absence of glucose intake.