Photo-crosslinked natural polyelectrolyte multilayer capsules for drug delivery

摘要

Polyelectrolyte multilayer (PEM) capsules have been widely investigated in drug delivery systems in past two decades, but still remain challenging for their uncontrolled release properties and kinetics. One way to control diffusion-based drug release is to crosslink the PEMs so that the permeability of capsules can be decreased and thus, the encapsulated drugs could be released with respect to the changes of chemical, physical or biological conditions. The photo-crosslinking method is approximately 16 times faster than the normal chemical methods. We hereby present a fast photo-crosslinking method of chitosan-alginate PEM capsules, which allows effectively decreasing the diffusion of the encapsulated components across the PEM walls of capsules. The experimental results show that photocrosslinked capsules exhibit a significantly lower release rate of anticancer drug, doxorubicine compared to non-crosslinked capsules, demonstrating the usability of this method in controlled drug delivery and biomedical applications. (C) 2015 Elsevier B.V. All rights reserved.