Kinetic Resolution of Oxazinones: Rational Exploration of Chemical Space through the Design of Experiments

摘要

The organocatalytic kinetic resolution of 4-substituted oxazinones has been optimised (selectivity factor S up to 98, chiral oxazinone ee values up to 99.6% (1a–g) and product ee values up to 90% (3a–g)) in a rational way by applying the Design of Experiments (DoE) approach.