Palladium-Catalyzed Alkoxycarbonylation of Terminal Alkenes To Produce a,p-Unsaturated Esters: The Key Role of Acetonitrile as a Ligand

摘要

A mild protocol has been developed for the Pd~(||)-catalyzed alkoxycarbonylation of terminal olefins to produce α,β-unsatu rated esters with a wide range of substrates. Key features are the use of MeCN as solvent (and/ or ligand) to control the reactivity of the intermediate Pd complexes and the combination of CO with O_2, which facilitates the Cu~(||)-mediated reoxidation of the Pd~0 complex to Pd~(||) and prevents double carbonylation.