Highly Enantioselective Addition of In Situ Prepared Arylzinc to Aldehydes Catalyzed by a Series of Atropisomeric Binaphthyl-Derived Amino Alcohols

摘要

The direct addition of in situ prepared arylzinc to aldehydes with chiral binaphthyl-derived amino alcohols as catalysts can afford optically active diaryl-methanols in high yields and with excellent enantioselectivities(up to 99% ee,ee=enantiomeric excess).By using a single catalyst,both enantiomers of many pharmaceutically interesting diarylmethanols can be obtained by the proper combination of various arylzinc reagents with different aldehydes;this catalytic system also works well for the phenylation of aliphatic aldehydes to give up to 96% ee.