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摘要

NK cell function, we cultured NK cells overnight with 1000 IU/mL of IL-2 in the presence/absence of 15 (xMCADO. We observed that CADO significantly suppresses IL-2 induced tumor necrosis factor-a and interferon--/ production by NK cells (Figure 1C-D). We also studied the effect of overnight CADO treatment on un-stimulated NK cells. When these CADO pretreated NK cells were exposed to K562 leukemic cells, the former exhibited significantly reduced degranulation capacity compared with NK cells cultured without CADO (Figure IE). ^t>The FIP1L1-PDGFRA fusion gene and the /C/7D816V mutation are coexisting in a small subset of myeloid/lymphoid neoplasms with eosinophilia