A single untimed plasma drug concentration measurement during low-level HIV viremia predicts virologic failure

摘要

Suboptimal untimed plasma drug levels (UDL) have been associated with lower rates of virologic suppression and the emergence of drug resistance. Our aim was to evaluate whether UDL among patients with low-level viremia (LLV) while receiving highly active antiretroviral therapy (HAART) can predict subsequent virologic failure (plasma viral load >= 1000 copies/mL) and emergence of resistance.