A novel macrocyclic lactone with insecticidal bioactivity from Streptomyces microflavus neau3

摘要

A novel macrocyclic lactone (1) was isolated from the fermentation broth of Streptomyces microflavus neau3, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed high acaricidal activity against adult mites (IC 50 = 11.1 μg mL -1), and nematocidal activity against Caenorhabditis elegans (IC 50 = 17.4 μg mL -1), especially the acaricidal activity against mite eggs with an IC 50 of 37.1 μg mL -1, which was relative higher than that of the commercial acaricide and nematocide milbemycins A 3/A 4.