Numb chin syndrome has been de- scribed in the literature since the 1960s and has been recognized as a sign of possible serious illness since that time.1 It is defined as a numbness or paresthesia over the territory of the mental nerve, which includes the chin and lower lip. This syndrome can result from non-malignant etiologies—such as trauma, drugs, diabetes niellitus, syphilis, amy-loidosis, sarcoidosis, sickle cell anemia, and vasculitis, but the most common and most worrisome cause is meta-static malignancy. Numb chin syndrome has most frequently been associated with breast cancer and lympho-ma; however, it has also been linked to many other malignancies.
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