Primary sensitization to toluene-2,5-diamine giving rise to early positive patch reaction to p-phenylenediamine and late to toluene-2,5-diamine.

摘要

Allergic reactions following the use of permanent hair dyes are well known and well described for both hairdressers and their clients. P-phenylenediamine (PPD) and toluene-2,5-diamine (PTD) are the two most widely used active constituents of permanent hair dyes (1). Both are extreme sensitizers (2). It has been shown, both in animal and patients studies, that there is a significant cross/co-reactivity between PPD and PTD, as well as for many other hair dye constituents (3, 4).