The use of 0.1-um rated sterilizing grade filters has been increasing in cell culture media filtration due to mycoplasma contamination concerns. Currently, no standards exist for conducting mycoplasma retention testing on these 0.1 -pm labeled filters. A task force has been established at PDA to publish a technical report to standardize testing. Until such guidelines are published, conducting side-by-side tests under identical conditions is the only fair way to compare different 0.1-um rated filters.Sartorius Stedim Biotech has conducted such tests on its Sartopore~R 2 0.2/0.1 PES 10 cartridge filters at a third party lab using a modified ASTM F838-05 method to show A Laidlawii removal at LRV = 7/cm~2.
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