Palladium Catalysis in Water: Design, Preparation, and Use of Amphiphilic Resin-Supported Palladium-Phosphine Complexes

摘要

Palladium-catalyzed synthetic transformations (pi-allylic substitution, carbonylation, cross-coupling, etc.) were achieved in water by use of amphiphilic polystyrene-poly(ethylene glycol) resin (PS-PEG)-supported plladium-phosphine complexes. Asymmetric allylic alkylation of cyclic allyl esters was catalyzed by a palladium complex of a PS-PEG-supported chiral (imidazoindole) phosphine ligand with high enantioselectivity of up to 99% ee.