A very severe case of feline amyloidosis with spontaneous hepatic rupture and chronic renal failure

摘要

A 3.5-year-old neutered male domestic shorthaired cat presenting with inappetence, depression, polydisia, and severe icteric mucous membranes was diagnosed as having systemic amyloidosis with spontaneous hemorrhage from the liver and chronic renal failure. Laboratory findings were remarkable for anemia, thrombocytopenia, mature neutro-philia, hyperbilirubinemia, azotemia, and hyperphosphatemia. Little treatment was possible and the cat was euthanased later. At necropsy, the entire abdominal cavity was filled with intra-abdominal hemorrhage. Histopathological examination revealed extensive deposition of eosinophilic homogenous material in the parenchyma of the liver and sinusoids. Hepatic amyloid was detected primarily in periacinar regions associated with atrophy of adjacent hepatocytes. In the kidney, marked eosinophilic homogenous material was found in numerous glomerali and outer medullary area. Amyloid deposits were demonstrated by the Congo red stain. Whether underlying diseases present as risk factors for the severity of clinical and biochemical picture of generalized amyloidosis in this case is unclear.