Effect of roflumilast on airway remodelling in a murine model of chronic asthma

Kim S. W.; Kim J. H.; Park C. K.; Kim T. J.; Lee S. Y.; Kim Y. K.; Kwon S. S.; Rhee C. K.; Yoon H. K.

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Effect of roflumilast on airway remodelling in a murine model of chronic asthma

机译：罗氟司特对慢性哮喘小鼠模型气道重塑的影响

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BackgroundAirway remodelling is associated with irreversible, or partially reversible, airflow obstruction and ultimately unresponsiveness to asthma therapies such as corticosteroids. Roflumilast is a selective phosphodiesterase-4 inhibitor that has an anti-inflammatory effect in chronic obstructive pulmonary disease (COPD).

机译：背景技术气道重塑与不可逆的或部分可逆的气流阻塞以及最终对哮喘疗法（如皮质类固醇）无反应有关。罗氟司特是一种选择性磷酸二酯酶4抑制剂，在慢性阻塞性肺疾病（COPD）中具有抗炎作用。

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《Clinical and experimental allergy :》 |2016年第5期|共10页
作者
Kim S. W.; Kim J. H.; Park C. K.; Kim T. J.; Lee S. Y.; Kim Y. K.; Kwon S. S.; Rhee C. K.; Yoon H. K.;
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正文语种 eng
中图分类医学免疫学;
关键词
airway inflammation; airway remodelling; asthma; roflumilast;

机译：气道炎症;气道重塑;哮喘;鲁氟司特;

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1. Effect of roflumilast on airway remodelling in a murine model of chronic asthma [J] . Kim S. W., Kim J. H., Park C. K., Clinical and experimental allergy : . 2016,第5期

机译：罗氟司特对慢性哮喘小鼠模型气道重塑的影响
2. HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts [J] . Changchun Hou, Jinliang Kong, Yue Liang, 中国免疫学杂志（英文版） . 2015,第004期

机译：HMGB1通过调节气道炎症和激活肺成纤维细胞，在慢性哮喘小鼠模型中促进变应原诱导的气道重塑
3. HMGB 1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts [J] . Changchun H ou, Jinliang Kong, Yue Liang, 细胞与分子免疫学：英文版 . 2015,第004期

机译：通过调节气道炎症和激活肺成纤维细胞，HMGB 1在慢性哮喘的鼠模型中有助于过敏原诱导的气道重塑
4. Airway eptihelial compression: a stimulus for airway remodeling in asthma [C] . Daniel J. Tschumperlin, Jonathan D. Shively, Ioanna Kosmidou, Bioengineering Conference . 2001

机译：气道上皮压缩：哮喘中气道重塑的刺激
5. Airway wall remodelling in chronic allergic airway disease. [D] . Johnson, Jill Rose. 2007

机译：慢性过敏性气道疾病的气道壁重塑。
6. HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts [O] . Changchun Hou, Jinliang Kong, Yue Liang, 2015

机译：HMGB1通过调节气道炎症和激活肺成纤维细胞在慢性哮喘的小鼠模型中促进变应原诱导的气道重塑
7. TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model [O] . Joon Young Choi, Hwa Young Lee, Jung Hur, 2018

机译：TRPV1阻断缓解了慢性哮喘鼠模型中的气道炎症和重塑

Effect of roflumilast on airway remodelling in a murine model of chronic asthma

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