Nano/Microfluidic Systems for Analysis of a Single Cell and Subcellular Biomolecules

摘要

Cells play a significant role as the fundamental unit of life, and studies on cell contribute to show the specific feature of life. Highly efficient and sensitive detection of the biomolecules or subcellular substances released from a single cell explains some important physiological processes. For single cell analysis not only complementary information of complex biological systems but also the actual functional interaction of biomolecules on the cellular and tissue structural basis can be revealed. Nano-microfluidic devices exhibit the possibility of integrating a variety of cellular or subcellular operations in the nanometre scale, it further allows the analysis with improved performance, throughput, parallelization and automation. For sensitive detection it is important to scale down the size of the channels so that they approach the relevant length scales of the molecules of interest.