For the past decade, the applications of Bio-MEMS grow exponentially in various fields including medical detection, food detection, agriculture and other industrials. Over the developed bio-chip devices, capillary electrophoresis (CE) chip is one of the most promising schemes since it is capable of separating and detecting the target bio-samples in the microfluidic system. In general, silicon wafer, glass, polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), Teflon are used as the substrate materials for bioanalytical detections. This study developed a novel thread-based microfluidic system capable of capillary electrophoresis separation, sample electrochemical detection, and even electrospray ionization. The developed thread-based microfluidic system is used to detect the blood urea nitrogen (BUN) and glucose (GLU) in human serum. The system can also be integrated with mass-spectrometry detection of natural products such as food ingredients. The thread-based microfluidic system developed in the present study provides a low-cost yet high performance was for analyzing biosamples or food samples.
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